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DAPT, Thermo Scientific Chemicals Product Code.: 15467109
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DAPT, Thermo Scientific Chemicals

Product Code. 15467109
10 mg
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Quantity:
10 mg
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Product Code. 15467109

Brand: Thermo Scientific Alfa Aesar J65864.MA

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Description

 

DAPT is used in the study of β-amyloid formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus, as well as in cancer cell growth, angiogenesis, and differentiation of human induced pluripotent stem cells.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
DAPT is used in the study of β-amyloid formation. DAPT has been shown to inhibit Notch signaling in studies of autoimmune and lymphoproliferative diseases, such as ALPS and lupus erythematosus, as well as in cancer cell growth,
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Specifications

CAS 208255-80-5
Color White
Molecular Formula C23H26F2N2O4
MDL Number MFCD04974585
Quantity 10 mg
Sensitivity Light Sensitive
Synonym dapt, dapt gsi-ix, gamma-secretase inhibitor ix, gsi-ix, insolution gamma-secretase inhibitor ix, s-tert-butyl 2-s-2-2-3,5-difluorophenyl acetamido propanamido-2-phenylacetate, n-n-3,5-difluorophenacetyl-l-alanyl-s-phenylglycine t-butyl ester, tert-butyl 2s-2-2s-2-2-3,5-difluorophenyl acetamido propanamido-2-phenylacetate, tert-butyl 2s-2-2s-2-2-3,5-difluorophenyl acetyl amino propanoyl amino-2-phenylacetate, gsiix
Solubility Information Soluble in DMSO,ethanol,dichloromethane,DMF.
InChI Key DWJXYEABWRJFSP-XOBRGWDASA-N
SMILES CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
IUPAC Name tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
Molecular Weight (g/mol) 432.468
PubChem CID 5311272
ChEBI CHEBI:86193
Formula Weight 432.5
Physical Form Lyophilized
Chemical Name or Material DAPT
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5 results found
Lot Number Certificate Type Date Catalog Number
Lot NumberN07L058 Certificate TypeCertificate of Analysis Date10/02/2025 Catalog NumberJ65864.MA
Lot NumberY27K012 Certificate TypeCertificate of Analysis Date02/12/2024 Catalog NumberJ65864.MA
Lot NumberX30K031 Certificate TypeCertificate of Analysis Date07/11/2024 Catalog NumberJ65864.MA
Lot NumberU06K061 Certificate TypeCertificate of Analysis Date23/08/2024 Catalog NumberJ65864.MA
Lot NumberR09K030 Certificate TypeCertificate of Analysis Date23/05/2024 Catalog NumberJ65864.MA

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