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Tocris Bioscience™ CU-76
Selective inhibitor of cyclic GMP-AMP synthase (cGAS)
Brand: Tocris Bioscience™ 7820/2
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Description
CU-76 is a selective cyclic GMP-AMP synthase (cGAS) inhibitor (IC50 = 0.24 μM). It specifically inhibits cGAS-STING pathway and has no effect on other nucleic acid sensing pathways such as the RIG-I-MAVS or Toll-like receptor pathways. CU-76 reduces DNA-induced IFN regulatory factor 3 (IRF3) dimerization in a dose-dependent manner, and it decreases production of IFN-β in THP-1 cells stimulated with interferon-stimulatory DNA.Specifications
| Methyl 4-amino-6-[(3,5-difluoro-4-iodophenyl)amino]-1,3,5-triazine-2-carboxylate | |
| 2 mg | |
| C11H8F2IN5O2 |
| 2400954-58-5 | |
| STING/TMEM173 | |
| 0.98 |