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STEMCELL Technologies Compound E

Notch pathway inhibitor; Inhibits Notch receptor and amyloid precursor protein

Specifications

CAS	209986-17-4
Synonym	γ-secretase inhibitor XXI
Molecular Formula	C₂₇H₂₄F₂N₄O₃
Purity	≥98%

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Product Code	Brand	Quantity	Price	Quantity & Availability
Product Code	Brand	Quantity	Price	Quantity & Availability
17110302 View Documents Promotion Details missing translation for 'viewProductCertificates'	STEMCELL Technologies 73954	1 mg	N/A View alternative products Save Up to »	N/A

17100302 View Documents Promotion Details missing translation for 'viewProductCertificates'	STEMCELL Technologies 73952	500 μg	N/A View alternative products Save Up to »	N/A

Description

Description

Compound E is a potent, cell-permeable, selective inhibitor that blocks the cleavage of both gamma-secretase and the Notch intracellular domain with similar IC50 values, ranging from 0.24 to 0.37 nM (Beher et al.; Seiffert et al.)
Inhibits growth, differentiation, and motility of neuroblastoma cells (Ferrari-Toninelli et al.)
Accelerates the differentiation of human embryonic stem cells into primitive neural stem cells (Li et al.)

Specifications

Specifications

CAS	209986-17-4
Synonym	γ-secretase inhibitor XXI
Molecular Formula	C₂₇H₂₄F₂N₄O₃
Purity	≥98%

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