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  7. Clozapine N-oxide, Tocris Bioscience™

Clozapine N-oxide, Tocris Bioscience™

Product Code. 30001356
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Activator of muscarinic DREADDs

Metabolite of clozapine (Cat. No. 0444). Activates human muscarinic designer receptors (DREADDs) in vitro. Silences hippocampal neurons expressing hM4 DREADDs in vitro. Activates Gs-linked DREADDS- AgRP in mice via intracerebroventricular (i.c.v) injection. Shown to be a P-glycoprotein (P-gp) efflux pump substrate. Other potent and selective hM3Dq DREADD agonists available: DREADD agonist 21 and Perlapine .

Water soluble salt also available.

This product contains 1 molar equivalent of ethanol.

Chemical Identifiers

CAS 34233-69-7
Molecular Formula C18H19ClN4O
Molecular Weight (g/mol) 342.827
InChI Key WYRDWWAASBTJLM-UHFFFAOYSA-N
Synonym clozapine n-oxide, clozapine-n-oxide, unii-mza8bk588j, chembl1688, mza8bk588j, n-oxyclozapine, clozapine n-oxide cno, oguczbiqsyywef-uhfffaoysa-n
PubChem CID 2819
IUPAC Name 3-chloro-6-(4-methyl-4-oxidopiperazin-4-ium-1-yl)-5H-benzo[b][1,4]benzodiazepine
SMILES C[N+]1(CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl)[O-]

Specifications

Assay Percent Range >98%
Quantity 50 mg
Formula Weight 342.82
Percent Purity >99%
Chemical Name or Material Clozapine N-oxide
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