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  6. CD85d (ILT4) Monoclonal Antibody (42D1), Functional Grade, eBioscience™, Invitrogen™

CD85d (ILT4) Monoclonal Antibody (42D1), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

30070.00 NOK - 150400.00 NOK

Specifications

Antigen CD85d (ILT4)
Clone 42D1
Concentration 1 mg/mL
Applications Flow Cytometry, Functional Assay
Classification Monoclonal
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17111282
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Affymetrix eBioscience
16-5149-38 		5 mg This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
 		N/A
17191272
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Affymetrix eBioscience
16-5149-025 		25 mg This item is currently unavailable or has been discontinued.
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17101282
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Affymetrix eBioscience
16-5149-050 		50 mg This item is currently unavailable or has been discontinued.
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 		N/A
Description

Description

The MAb 42D1 recognizes the CD85d protein also known as ILT4, LIR-2. It is a member of the ILT (immunoglobulin-like transcript)/ LIR (leukocyte Ig-like receptor), MIR (monocytes Ig-like receptor) family. CD85d is a 110 kDa single transmembrane receptor with 3 Ig-like domains and a long cytoplasmic domain containing ITIMs (immunoreceptor tyrosine-based inhibitory motifs). Expression is confined to monocytes, macrophages and dendritic cells. The ligand for CD85d is non-classical class I HLA-G, -B and G1. Upon ligand binding, tyrosine phosphatase SHP-1 interacts with the ITIM. Interaction of HLA-G with ILT4/CD85d is thought to contribute to tolerance during fetal implantation. Additionally, it is the levels of ILT3 and ILT4 on DCs that suggests a role in organ allograft rejection. Crosslinking of the receptor with the MAb 42D1 inhibits calcium flux as well as enhancing HLA-G tetramer staining and restoring the stimulating activity of tolerogenic DC.

CD85d (ILT4) Monoclonal antibody specifically detects CD85d (ILT4) in Human samples. It is validated for Flow Cytometry, Functional Assay
Specifications

Specifications

CD85d (ILT4)
1 mg/mL
Monoclonal
Liquid
RUO
PBS with no preservative; pH 7.2
CD85 antigen-like family member D; CD85D; CD85d antigen; Ig-like transcript 4; ILT4; ILT-4; leucocyte Ig-like receptor B2; leukocyte immunoglobulin like receptor B2; leukocyte immunoglobulin-like receptor subfamily B member 2; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; LILRB2; LIR2; LIR-2; LIR2CD85D; MIR10; MIR-10; MIR10LILRA6; monocyte/macrophage immunoglobulin-like receptor 10; myeloid inhibitory receptor 10
IgG2a κ
Affinity chromatography
Antibody
42D1
Flow Cytometry, Functional Assay
Functional Grade
Rat
Human
Q8N423
10288
Primary
4° C
LILRB2
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