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CD45R (B220) Rat, anti-Mouse, Unconjugated, Clone: RA3-6B2, STEMCELL Technologies
Rat Monoclonal Antibody
Brand: Stemcell Technologies 60019
This item is not returnable.
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Description
- The RA3-6B2 antibody reacts with an epitope on the extracellular domain of the exon A‐restricted isoform of mouse CD45
- CD45 is a member of the protein tyrosine phosphatase family and functions in a number of immunoregulatory processes, including cell activation, growth, differentiation, and oncogenic transformation
- The large cytoplasmic portion of CD45 contains two tyrosine phosphatase domains (one of which is enzymatically active) that are involved in modulating the function of Src kinases such as Lck and Fyn
- Several isoforms of CD45 have been identified, the expression of which differs according to cell type and functional status
- Alternative splicing of three exons encoding the extracellular RA, RB, and RC polypeptide sequences gives rise to up to 8 isoforms with molecular masses in the range of 200 - 220 kDa
- This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Mouse B Cell Isolation Kit (Catalog #19854)
Specifications
| CD45R (B220) | |
| Monoclonal | |
| Unconjugated | |
| 500 μg | |
| Feline, Human, Mouse | |
| B Cells, Leukocytes, Lymphocytes |
| Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence | |
| RA3-6B2 | |
| Rat | |
| Primary | |
| IgG2a κ |
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