CD31 (PECAM-1) Chimeric Recombinant Rabbit Monoclonal Antibody (BAG-85D10), Invitrogen™

Description

Specificity: This antibody recognises CD31 (PECAM1) which is a member of the immunoglobulin superfamily and is expressed at various circulatng cells, such as neutrophils, monocytes, platelets as well as on endothelial cells. CD31 is a cell adhesion molecule and is involved in the leukocyte transendothelial migration during inflammation.

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.