missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. CD180 (RP105) Monoclonal Antibody (MHR73-11), Functional Grade, eBioscience™, Invitrogen™
  7. 17101182

CD180 (RP105) Monoclonal Antibody (MHR73-11), Functional Grade, eBioscience™, Invitrogen™

Mouse Monoclonal Antibody

Brand:  Affymetrix eBioscience 16-1809-050

 View more versions of this product

Product Code. 17101182

This item is currently unavailable or has been discontinued.
View the product page for possible alternatives.
 View alternative products »

Explore more special offers
This item is not returnable. View return policy

Description

Description

The MHR73-11 MAb reacts with human CD180 (RP105). This 105 kDa type I transmembrane molecule is a member of the TLR family of proteins characterized by an extracellular domain with leucine-rich repeats and a cytoplasmic domain with homology to the type I IL-1 receptor. RP105 physically associates with another molecule called MD-1 and is expressed on B, monocytes/macrophages, and dendritic cells. Histological studies show that RP105 is expressed mainly on mature B cells in mantle zones, while germinal center cells are either dull or negative. The RP105/MD-1 complex in concert with TLR4 mediates B cell recognition and signaling of LPS. MHR73-11 activates B cells, leading to increases in cell size, expression of the costimulatory molecule CD80, and DNA synthesis. Moreover, ligation of RP105 protects B cells from irradiation- or dexamethasone-induced apoptosis. Thus, RP105 is a signal transduction molecule and plays a role in regulation of B cell growth and death. A significant proportion of circulating B cells in SLE patients is RP105 negative. Loss of RP105 is associated with B cell activation and increased disease activity in SLE patients.

CD180 (RP105) Monoclonal antibody specifically detects CD180 (RP105) in Human samples. It is validated for Flow Cytometry, Functional Assay
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CD180 (RP105)
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.2
Q99467
Mouse
50 mg
Primary
Human
Antibody
IgG1 κ
Flow Cytometry, Functional Assay
MHR73-11
Functional Grade
Cd180
Cd180; CD180 antigen; CD180 molecule; F630107B15; LY64; Ly78; Ly-78; lymphocyte antigen 64; Lymphocyte antigen 78; lymphocyte antigen-64, radioprotective, 105kDa; MGC126233; MGC126234; Radioprotective 105 kDa protein; RP105
Affinity chromatography
RUO
4064
4° C
Liquid
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

Certificates
Special Offers

Special Offers

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.