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STEMCELL Technologies CAY10603

Epigenetic modifier; Inhibits histone deacetylase (HDAC) 6

Brand: STEMCELL Technologies 73582

Product Code. 17190242

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Description

CAY10603 is a selective and potent inhibitor of histone deacetylase 6 (HDAC6; IC₅₀ = 0.002 nM; Kozikowski et al.) HDAC6 deacetylates lysine residues on the N-terminal part of histones
HDAC6 is also known to regulate heat shock protein 90 (hsp90) via hyperacetylation (Rao et al.)
Inhibits growth of several pancreatic cancer cell lines (IC₅₀ = 0.1 - 1 μM) and SCCOHT, an ovarian cancer cell line (Kozikowski et al.; Wang et al.)

Specifications

Synonym	HDAC6 inhibitor
Molecular Formula	C₂₂H₃₀N₄O₆

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