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BAY 41-8543, >98%, Tocris Bioscience™

Product Code. 30001039
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Quantity:
10 mg
50 mg
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This item is not returnable. View return policy

Description

Guanylyl cyclase (sGC) stimulator

Guanylyl cyclase (sGC) stimulator. Increases activity of sGC by up to 92-fold at concentrations up to 100 μM. Induces relaxation of aorta, saphenous arteries, coronary arteries and veins in vitro. Inhibits collagen-induced platelet aggregation. Promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. Induces weight loss in obese mice. Antihypertensive.

Chemical Identifiers

CAS 256498-66-5
Molecular Formula C21H21FN8O
Molecular Weight (g/mol) 420.452
InChI Key AQYFUZRYBJBAGZ-UHFFFAOYSA-N
Synonym unii-323t2c09sg, 2-1-2-fluorophenyl methyl-1h-pyrazolo 3,4-b pyridin-3-yl-5-4-morpholinyl-4,6-pyrimidinediamine, 4,6-pyrimidinediamine, 2-1-2-fluorophenyl methyl-1h-pyrazolo 3,4-b pyridin-3-yl-5-4-morpholinyl, 2-1-2-fluorophenyl methyl-1h-pyrazolo 3,4-b pyridin-3-yl-5-morpholin-4-yl pyrimidine-4,6-diamine, 2-1-2-fluorophenyl methyl pyrazolo 3,4-b pyridin-3-yl-5-morpholin-4-yl pyrimidine-4,6-diamine
PubChem CID 9953906
IUPAC Name 2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]-5-morpholin-4-ylpyrimidine-4,6-diamine
SMILES C1COCCN1C2=C(N=C(N=C2N)C3=NN(C4=C3C=CC=N4)CC5=CC=CC=C5F)N

Specifications

Linear Formula C21H21FN8O
Quantity 10 mg
Solubility Information Soluble to 10mM in DMSO with gentle warming
Formula Weight 420.44
Percent Purity >98%
Chemical Name or Material 2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamin
Grade >98%
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