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BAY 41-2272, Tocris Bioscience™

Product Code. 18065322
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Quantity:
10 mg
50 mg
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Description

Soluble guanylyl cyclase (sGC) activator

Activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.

Chemical Identifiers

CAS 256376-24-6
Molecular Formula C20H17FN6
Molecular Weight (g/mol) 360.40
MDL Number MFCD06411391
InChI Key ATOAHNRJAXSBOR-UHFFFAOYSA-N
Synonym unii-34a162j6wb, 3-4-amino-5-cyclopropylpyrimidin-2-yl-1-2-fluorobenzyl-1h-pyrazolo 3,4-b pyridine, 5-cyclopropyl-2-1-2-fluorobenzyl-1h-pyrazolo 3,4-b pyridin-3-yl pyrimidin-4-ylamine, 5-cyclopropyl-2-1-2-fluorophenyl methyl-1h-pyrazolo 3,4-b pyridin-3-yl-4-pyrimidinamine, 5-cyclopropyl-2-1-2-fluorophenyl methyl-1h-pyrazolo 3,4-b pyridin-3-yl pyrimidin-4-amine, 5-cyclopropyl-2-1-2-fluorophenyl methyl pyrazolo 3,4-b pyridin-3-yl pyrimidin-4-amine, d0o9cz, 4-pyrimidinamine, 5-cyclopropyl-2-1-2-fluorophenyl methyl-1h-pyrazolo 3,4-b pyridin-3-yl, bay hplc, 5-cyclopropyl-2-1-2-fluorobenzyl-1h-pyrazolo 3,4-b pyridin-3-yl pyrimidin-4-amine
PubChem CID 9798973
IUPAC Name 5-cyclopropyl-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-4-amine
SMILES NC1=NC(=NC=C1C1CC1)C1=NN(CC2=CC=CC=C2F)C2=NC=CC=C12

Specifications

Quantity 10 mg
Formula Weight 360.39
Percent Purity >98%
Chemical Name or Material BAY 41-2272
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