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Tocris Bioscience™ AZD 7648

Potent and selective DNA-PK inhibitor

Brand:  Tocris Bioscience™ 7825/10

1621.56 NOK valid until 2024-12-16
Use promo code "21630" to get your promotional price.


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Product Code. 18779796

  • 2095.00 NOK / 10mg

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Description

Description

AZD 7648 is a potent (IC50 = 0.6 nM in an enzyme assay) and selective DNA-PK inhibitor. It is selective for DNA-PK over a range of kinases including PI3Kα, PI3Kδ, PI3Kγ, ATM, ATR and mTOR. In combination with radiotherapy, it leads to tumor regression in fully immuno-competent mice models. It also enhances the activity of PARP inhibitor Olaparib (Cat. No. 7579). AZD 7648 is orally bioavailable.
Specifications

Specifications

7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one
10 mg
C18H20N8O2
2230820-11-6
DNA-dependent Protein Kinase Inhibitors
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