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  6. 8-Chloroadenosine, Tocris Bioscience™

8-Chloroadenosine, Tocris Bioscience™

Product Code. 30001511
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Quantity:
10 mg
50 mg
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Description

Cytotoxic nucleoside analog; inhibits RNA synthesis

Nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226 and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells.

Chemical Identifiers

CAS 34408-14-5
Molecular Formula C10H12ClN5O4
Molecular Weight (g/mol) 301.687
InChI Key MHDPPLULTMGBSI-FTWQFJAYSA-N
Synonym 8-chloroade-nosine
PubChem CID 13009312
IUPAC Name (2R,3R,4R,5R)-2-(6-amino-8-chloropurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
SMILES C1=NC2=C(C(=N1)N)N=C(N2C3C(C(C(O3)CO)O)O)Cl

Specifications

Quantity 10 mg
Formula Weight 301.69
Percent Purity >98%
Chemical Name or Material 8-Chloroadenosine
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