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5-Iodotubercidin, Tocris Bioscience™
Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases
Brand: Tocris Bioscience 1745/1
| Quantity | 1 mg |
|---|
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Description
Potent adenosine kinase inhibitor (IC50 = 26 nM). Also nucleoside transporter inhibitor (IC50 values are < 25 nM, 7 ÎĽM and 15 ÎĽM for inhibition of [3H]adenosine, [3H]uridine and [3H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 ÎĽM respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo.
Specifications
| 24386-93-4 | |
| MFCD00055131 | |
| 5-iodotubercidin, 5-iodotubericidin, 7-iodo-7-deazaadenosine, 7-iodotubercidin, 2r,3r,4s,5r-2-4-amino-5-iodo-7h-pyrrolo 2,3-d pyrimidin-7-yl-5-hydroxymethyl tetrahydrofuran-3,4-diol, 7-deaza-7-iodoadenosine, chembl99203, 7h-pyrrolo 2,3-d pyrimidin-4-amine,5-iodo-7-b-d-ribofuranosyl, 5-iodo-7-beta-d-ribofuranosyl-7h-pyrrolo 2,3-d pyrimidin-4-amine | |
| NC1=C2C(I)=CN(C3OC(CO)C(O)C3O)C2=NC=N1 | |
| 392.15 | |
| CHEBI:40167 | |
| 97% |
| C11H13IN4O4 | |
| 1 mg | |
| WHSIXKUPQCKWBY-UHFFFAOYNA-N | |
| 2-{4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-5-(hydroxymethyl)oxolane-3,4-diol | |
| 97297 | |
| 392.15 | |
| 5-Iodotubercidin |
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Product Title
5-Iodotubercidin, Tocris Bioscience™ > 1mg
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