missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Biochemical Reagents
  4. Nucleosides and Analogues
  5. Pyrrolopyrimidine nucleosides and nucleotides
  6. 18054072

5-Iodotubercidin, Tocris Bioscience™

Product Code. 18054072
Click to view available options
Quantity:
1 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases

Potent adenosine kinase inhibitor (IC50 = 26 nM). Also nucleoside transporter inhibitor (IC50 values are < 25 nM, 7 μM and 15 μM for inhibition of [3H]adenosine, [3H]uridine and [3H]formycin B uptake respectively). Strongly stimulates glycogen synthesis in hepatocytes via activation of glycogen synthase. Also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2 and PKC (IC50 values are 0.4, 3.5, 5-10, 5-10, 10.9 and 27.7 μM respectively). Decreases hippocampal DNA methylation through adenosine kinase inhibition in vivo.

Specifications

CAS 24386-93-4
Molecular Formula C11H13IN4O4
MDL Number MFCD00055131
Quantity 1 mg
Synonym 5-iodotubercidin, 5-iodotubericidin, 7-iodo-7-deazaadenosine, 7-iodotubercidin, 2r,3r,4s,5r-2-4-amino-5-iodo-7h-pyrrolo 2,3-d pyrimidin-7-yl-5-hydroxymethyl tetrahydrofuran-3,4-diol, 7-deaza-7-iodoadenosine, chembl99203, 7h-pyrrolo 2,3-d pyrimidin-4-amine,5-iodo-7-b-d-ribofuranosyl, 5-iodo-7-beta-d-ribofuranosyl-7h-pyrrolo 2,3-d pyrimidin-4-amine
InChI Key WHSIXKUPQCKWBY-UHFFFAOYNA-N
SMILES NC1=C2C(I)=CN(C3OC(CO)C(O)C3O)C2=NC=N1
IUPAC Name 2-{4-amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl}-5-(hydroxymethyl)oxolane-3,4-diol
Molecular Weight (g/mol) 392.15
PubChem CID 97297
ChEBI CHEBI:40167
Formula Weight 392.15
Percent Purity 97%
Chemical Name or Material 5-Iodotubercidin
Show More Show Less
missing translation for 'provideContentCorrection'

missing translation for 'productTitle'

missing translation for 'byClickingSubmit' missing translation for 'privacyPolicy'.