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STEMCELL Technologies 3-Deazaneplanocin A
Epigenetic modifier; Inhibits histone EZH2 lysine methyltransferase
1723.49 NOK - 3401.64 NOK
Specifications
CAS | 102052-95-9 |
---|---|
Synonym | DZNep; NSC 617989 |
Molecular Formula | C12H14N4O3 |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17170052
|
STEMCELL Technologies
72322 |
500 μg |
1723.49 NOK
500µg |
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17180052
|
STEMCELL Technologies
72324 |
1 mg |
3401.64 NOK
1mg |
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Description
- Deazaneplanocin A (DZNep) is an inhibitor of lysine methyltransferases, particularly EZH2
- DZNep therefore acts as an epigenetic modifier, specifically inhibiting the trimethylation of Histone 3, Lysine 27, by depleting levels of EZH2
- (Miranda et al.), Tan et al.), Tseng et al.)
- Enables chemical reprogramming (without genetic factors) of mouse embryonic fibroblasts to induced pluripotent stem (iPS) cells, in combination with CHIR99021, Forskolin, VaLproic Acid, Tranylcypromine, and E-616452, by increasing OCT4 expression at later stages of reprogramming (Hou et al.)
- Reactivation of XIST-dependent inactive X chromosomes in human embryonic stem cells (Diaz Perez et al.)
- Inhibits self-renewal of glioblastoma multiforme cancer stem cells (Suva et al.)
- Inhibits survival of acute myeloid leukemia blast cells, in combination with a histone deacetylase inhibitor (Fiskus et al.)
Specifications
102052-95-9 | |
DZNep; NSC 617989 | |
C12H14N4O3 |