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2-APB, Tocris Bioscience™

Product Code. 18075342
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Quantity:
10 mg
50 mg
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Description

IP3 receptor antagonist. Also TRP channel modulator

A functional and membrane permeable D-myo-inositol 1,4,5-trisphosphate (IP3) receptor antagonist (IC50 = 42 μM). Stimulates store-operated calcium (SOC) release at low concentrations (< 10 μM) and inhibits it at higher concentrations (up to 50 μM). Increases STIM-Orai channel conductance and limits ion selectivity. Modulator of TRP channels; blocks TRPC1, TRPC3, TRPC5, TRPC6, TRPV6, TRPM3, TRPM7, TRPM8 and TRPP2 and at higher concentrations stimulates TRPV1, TRPV2 and TRPV3. Also blocks specific gap channel subtypes.

Chemical Identifiers

CAS 524-95-8
Molecular Formula C14H16BNO
Molecular Weight (g/mol) 225.10
MDL Number MFCD00014823
InChI Key BLZVCIGGICSWIG-UHFFFAOYSA-N
Synonym 2-aminoethyl diphenylborinate, 2-apb, 2-aminoethoxy diphenylborane, 2-aminoethoxydiphenylborane, 2-aminoethoxydiphenylborate, 2-aminoethoxydiphenyl borate, o-2-aminoethyl diphenylborinic acid, b-2-aminoethoxy diphenylborane, 2-diphenylboryl oxy ethanamine, borinic acid, o-2-aminoethyl diphenyl
PubChem CID 1598
IUPAC Name 2-aminoethyl diphenylborinate
SMILES NCCOB(C1=CC=CC=C1)C1=CC=CC=C1

Specifications

Quantity 10 mg
Formula Weight 225.1
Percent Purity >98%
Chemical Name or Material 2-APB
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