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  6. 2,2,2-Trifluoroethanol, 99+%, Thermo Scientific Chemicals

2,2,2-Trifluoroethanol, 99+%, Thermo Scientific Chemicals

Product Code. 11484130
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Description

Trifluoroethanol serves as a solvent and a raw material in organic chemistry and biology. TFE is a solvent of choice for hydrogen peroxide-mediated oxidations of sulfides. Trifluoroethanol acts as a protein denaturant. It is used in the manufacture of certain pharmaceuticals and drug substances. The drug fluromer, which is 2,2,2-trifluoro-1-vinyloxyethane, is the vinyl ether of trifluorethanol. It is an effective solvent for peptides and proteins, and used for NMR-based protein folding studies, and in the manufacture of nylon. As a source of the trifluoromethyl group, it is employed in several organic reactions, for example in Still-Gennari modification of Horner-Wadsworth-Emmons reaction (HWE) reaction.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trifluoroethanol serves as a solvent and a raw material in organic chemistry and biology. TFE is a solvent of choice for hydrogen peroxide-mediated oxidations of sulfides. Trifluoroethanol acts as a protein denaturant. It is used in the manufacture of certain pharmaceuticals and drug substances. The drug fluromer, which is 2,2,2-trifluoro-1-vinyloxyethane, is the vinyl ether of trifluorethanol. It is an effective solvent for peptides and proteins, and used for NMR-based protein folding studies, and in the manufacture of nylon. As a source of the trifluoromethyl group, it is employed in several organic reactions, for example in Still-Gennari modification of Horner-Wadsworth-Emmons reaction (HWE) reaction.

Solubility
Miscible with water, ethers, ketones, alcohols and chloroform.

Notes
Moisture sensitive.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 75-89-8
Molecular Formula C2H3F3O
Molecular Weight (g/mol) 100.04
MDL Number MFCD00004672
InChI Key RHQDFWAXVIIEBN-UHFFFAOYSA-N
Synonym trifluoroethanol, ethanol, 2,2,2-trifluoro, 2,2,2-trifluoroethan-1-ol, fluorinol 85, 2,2,2-trifluoroethyl alcohol, trifluoroethyl alcohol, trifluoro ethanol, tfe, perfluoro-1,1-dihydroethanol, tfetoh
PubChem CID 6409
ChEBI CHEBI:42330
SMILES OCC(F)(F)F

Specifications

Melting Point -44°C
Density 1.391
Boiling Point 74°C to 75°C
Flash Point 29°C (84°F)
Linear Formula CF3CH2OH
Refractive Index 1.29
Quantity 500 g
UN Number UN1992
Beilstein 1733203
Solubility Information Miscible with water,ethers,ketones,alcohols and chloroform.
IUPAC Name 2,2,2-trifluoroethanol
Formula Weight 100.04
Percent Purity ≥99%
Chemical Name or Material 2,2,2-Trifluoroethanol
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Safety and Handling

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Product Identifier
  • 2,2,2-Trifluoroethanol
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 3
  • Serious eye damage/eye irritation Category 1
  • Flammable liquid Category 3
  • Reproductive toxicity Category 1B
  • Specific target organ toxicity after repeated exposure Category 2
 Hazard Statement
  • H226-Flammable liquid and vapour.
  • H301-Toxic if swallowed.
  • H318-Causes serious eye damage.
  • H331-Toxic if inhaled.
  • H360F-May damage fertility.
  • H373-May cause damage to organs.
 Precautionary Statement
  • P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P302+P352-IF ON SKIN: Wash with plenty of water/soap.
  • P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
  • P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
  • P310-Immediately call a POISON CENTER/doctor/.
 Supplemental information
  • MIXTURE LIST-Contains : 2,2,2-Trifluoroethanol

RUO – Research Use Only

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