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Tocris™ 1A-116
Rac1 inhibitor; blocks Rac1-P-Rex1 interaction
Brand: Tocris™ 6701/10
2242.55 NOK valid until 2024-12-16
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Description
1A-116 is a Rac1 inhibitor. Reduces intracellular Rac1-GTP levels and blocks Rac1-P-Rex1 interaction in vitro. Exhibits no effect on GTPase activity of closely related Cdc42. Displays antiproliferative, anti-invasive and pro-apoptotic activity in several cancer cell lines. Exhibits antimetastatic activity in vivo. Also restores antiproliferative effects of Tamoxifen (Cat. No. 6342) in resistant breast cancer cell.Specifications
| N-(3,5-Dimethylphenyl)-N-[2-(trifluoromethyl)phenyl]guanidine | |
| 10 mg | |
| 307.31 | |
| 98% |
| 1430208-73-3 | |
| C16H16F3N3 | |
| Inhibitor |