CAS RN 946387-07-1
CAS RN 946387-07-1
IUPAC Name:
2,4-dichloro-N-(propan-2-yl)-N-{2-[(propan-2-yl)amino]ethyl}benzene-1-sulfonamide
Synonyms:
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
Molecular Weight (g/mol):
353.3
Molecular Formula:
C14H22Cl2N2O2S
InChi Key:
IHYZMEAZAIFMTN-UHFFFAOYSA-N
SMILES:
CC(C)NCCN(C(C)C)S(=O)(=O)C1=C(Cl)C=C(Cl)C=C1
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1
Tocris RN 1734
Selective TRPV4 antagonist
2
Medchem Express RN-1734, MedChemExpress
MedChemExpress RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC50s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM). RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells.
