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In the LanthaScreenâ„¢ Eu Kinase Binding Assay, binding of an Alexa Fluorâ„¢ conjugate or tracer such as Kinase Tracer 236 to a kinase is detected by addition of a Eu-labeled anti-tag antibody.
The JAK/STAT1 signaling pathway is known to be activated by type I/II interferons such as interferon-gamma and interferon-alpha.
The Tangoâ„¢ AGTRL1-bla U2OS cells contain the human Angtiotension-Like Receptor 1 (AGTRL1) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tangoâ„¢ GPCR-bla U2OS parental cell line.
The CRE-bla Jurkat cell line contains a beta-lactamase reporter gene under control of a cAMP response element (CRE) stably integrated into Jurkat cells.
LanthaScreenâ„¢ GFP Cellular Assays allow for the analysis of post-translational modifications for a number of target proteins in an live-cell context.
Neurotrophins (NGF, BDNF, NT-3, and NT-4) and their transmembrane receptors (TrkA, TrkB, TrkC, and P75NTR) play important roles in the regulation of neuronal and non-neuronal cell proliferation, differentiation, survival, and death.
GeneBLAzerâ„¢ LXR alpha DA (Division Arrested) cells and LXR alpha-UAS-bla HEK 293T 293 cells contain the ligand-binding domain (LBD) of the human Liver-X receptor-alpha(LXR alpha) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzerâ„¢ UAS-bla HEK 293T cell line.
The GeneBLAzerâ„¢ PAC1-CRE-bla CHO-K1 cells contain the human Adenylate Cyclase Activating Polypeptide 1 Receptor 1 (ADCYAP1R/PAC1) stably integrated into the CellSensorâ„¢ CRE-bla CHO-K1 cell line.
BacMam LRRK2-GFP G2019S Reagent is a modified insect cell virus (baculovirus) that enables easy, efficient, and titratable overexpression of full-length LRRK2-GFP G2019S in your choice of cellular background, including primary neurons and neuroblastoma cell lines.
The Tangoâ„¢ CCR5-bla U2OS cells contain the human Chemokine (C-C Motif) Receptor 5 (CCR5) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tangoâ„¢ GPCR-bla U2OS parental cell line.
GeneBLAzerâ„¢ERR alpha DA(Division Arrested) cells and ERR alpha-UAS-bla HEK 293T cells contain the ligand-binding domain (LBD) of the human Estrogen related receptor alpha (ERR alpha) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzerâ„¢UAS-bla HEK 293T cell line.
The GeneBLAzerâ„¢ CMV-bla Jurkat Cell Line constitutively expresses beta-lactamase under the control of the CMV promoter in Jurkat cells.
GeneBLAzer™ EDG3-Gα15 HEK 293T DA (Division Arrested) cells and EDG3-Gα15-NFAT-bla HEK 293T cells contain the human EDG3 receptor stably integrated in the GeneBLAzer™ Gα15-NFAT-bla HEK 293T cell line.
GeneBLAzerâ„¢ PTGDR CHO-K1 DA (Division Arrested) cells and PTGDR-CRE-bla CHO-K1 cells contain the human Prostanoid (PTGDR) receptor stably integrated into the CellSensorâ„¢ CRE-bla CHO-K1 cell line.
GeneBLAzerâ„¢ GCGR-CRE-bla CHO-K1 Cells contain the human glucagon receptor (GCGR).