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In the LanthaScreenâ„¢ Eu Kinase Binding Assay, binding of an Alexa Fluorâ„¢ conjugate or tracer such as Kinase Tracer 236 to a kinase is detected by addition of a Eu-labeled anti-tag antibody.
The JAK/STAT1 signaling pathway is known to be activated by type I/II interferons such as interferon-gamma and interferon-alpha.
The Tangoâ„¢ AGTRL1-bla U2OS cells contain the human Angtiotension-Like Receptor 1 (AGTRL1) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tangoâ„¢ GPCR-bla U2OS parental cell line.
The CRE-bla Jurkat cell line contains a beta-lactamase reporter gene under control of a cAMP response element (CRE) stably integrated into Jurkat cells.
LanthaScreenâ„¢ GFP Cellular Assays allow for the analysis of post-translational modifications for a number of target proteins in an live-cell context.
Neurotrophins (NGF, BDNF, NT-3, and NT-4) and their transmembrane receptors (TrkA, TrkB, TrkC, and P75NTR) play important roles in the regulation of neuronal and non-neuronal cell proliferation, differentiation, survival, and death.
BacMam LRRK2-GFP Wild Type Reagent is a modified insect cell virus (baculovirus) that enables easy, efficient, and titratable overexpression of full-length wild type LRRK2-GFP in your choice of cellular background, including primary neurons and neuroblastoma cell lines.
GeneBLAzerâ„¢GR DA (Division Arrested) cells and GR-UAS-bla HEK 293T cells contain the ligand-binding domain (LBD) of the human Gluocorticoid receptor (GR) fused to the DNA-binding domain of GAL4 stably integrated in the GeneBLAzerâ„¢UAS-bla HEK 293T cell line.
The GeneBLAzer™ Gα15-NFAT CHO-K1 DA (Division Arrested) cell line contains the promiscuous G protein, Gα15, stably integrated into the CellSensor™ NFAT-bla CHO-K1 cell line.
GeneBLAzerâ„¢ GCGR-CRE-bla CHO-K1 Cells contain the human glucagon receptor (GCGR).
The Tangoâ„¢ OPRL1-bla U2OS cells contain the human Opioid Receptor-Like 1 (OPRL1) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tangoâ„¢ GPCR-bla U2OS parental cell line.
The Map Kinase (MapK) signal transduction cascade is activated by growth factors such as EGF, PDGF, and HGF.
The Tangoâ„¢ CNR2-bla U2OS cells contain the human Cannabinoid Receptor 2 (CNR2) linked to a TEV protease site and a Gal4-VP16 transcription factor stably integrated into the Tangoâ„¢ GPCR-bla U2OS parental cell line.
GeneBLAzerâ„¢ PTGDR CHO-K1 DA (Division Arrested) cells and PTGDR-CRE-bla CHO-K1 cells contain the human Prostanoid (PTGDR) receptor stably integrated into the CellSensorâ„¢ CRE-bla CHO-K1 cell line.